Target Assessment
At Biomolix, we help make confident early-stage decisions by rigorously evaluating the therapeutic target. The results: clear, evidence-backed target validation package that reduces risk before significant resources are committed and sets the stage for successful lead discovery.
Target selection guidance. We help prioritize targets based on biological relevance, tractability, and alignment with your therapeutic goals.
Mechanistic hypothesis refinement. We work with your team to sharpen or challenge the underlying biological rationale and to guide informative experiments.
Druggability assessment. Not every target is amenable to modulation. We assess functional and structural characteristics to determine whether your target can be effectively drugged and by what modality.
Competitive landscape analysis. We research and provide a current view of on-going activities. This intelligence helps identify differentiation opportunities and crafts a strategy that stands out to partners and investors.
Hit Finding
At Biomolix, we help identify high-quality hits using scientific rigor and strategic foresight. The results: credible and differentiated hits ready to evolve into leads and supported by a thoughtful strategy.
Assay design and screening. We help design robust assays (biochemical, biophysical, and/or cell-based) and guide the screening approach to maximize chances of success.
Mechanism of action (MoA). Understanding how a molecule engages its target is key to advancing the right hits. We help elucidate MoA early using orthogonal assays to prioritize the most promising chemotypes.
Structure-based drug discovery (SBDD) enablement. We support SBDD efforts by helping to ensure the right tools (crystallography-grade proteins, crystal structures, ligandability data, binding models) are in place so medicinal chemistry is guided by data.
Optimization cascade design. We help build a rational cascade of assays and decision points that prioritize potency, selectivity, mechanism, and developability, ensuring efficient progression through SAR.
Scientific Oversight
At Biomolix, we step in as an extension of your team to provide scientific oversight and keep programs on track. The results: efficient and high-quality execution without the overhead of building a full team.
Vendor selection and management. We help identify and evaluate specialized vendors based on capabilities, track record, and technical fit and ensure contracts and budget align with program goals.
Study design and data review. We help design studies that generate clear and decision-driving data, and we review results with a critical eye to ensure scientific robustness.
Oversight of CRO activities. We serve as your scientific liaison, overseeing CRO activities to ensure high-quality execution, clear communication, and adherence to timelines.
Interim/fractional scientific support. We help with fractional leadership providing decision-making support and cross-functional coordination when and where you need it.
Short Courses
Coming soon from Biomolix!